Pinpointing Biomarkers in Proteomic LC/MS Data by Moving-Window Discriminant Analysis
نویسندگان
چکیده
منابع مشابه
Pinpointing biomarkers in proteomic LC/MS data by moving-window discriminant analysis.
The identification of differential patterns in data originating from combined measurement techniques such as LC/MS is pivotal to proteomics. Although "shotgun proteomics" has been employed successfully to this end, this method also has severe drawbacks, because of its dependence on largely untargeted MS/MS sequencing and databases for statistical analyses. Alternatively, several MS-signal-based...
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ژورنال
عنوان ژورنال: Analytical Chemistry
سال: 2011
ISSN: 0003-2700,1520-6882
DOI: 10.1021/ac200334s